Tianeptine nod. Tianeptine as a glutamatergic modulator, among other mechanisms, allows us to approach depression from a different point of view than other Tianeptine is an antidepressant that acts on glutamate and opioid receptors, offering fast relief for depression and anxiety. 5, Dick Durbin, Richard Blumenthal and Frank Pallone, Jr. ” The FDA is warning the public about "gas station heroin," or products that contain tianeptine, an opioid alternative prescribed as an antidepressant in some countries. " Tianeptine is an over the counter antidepressant that mimics opiates in some ways and can be highly addictive. New York, USA - Tianeptine market is estimated to reach USD xx Billion by 2024. It increases serotonin (5-hydroxytryptamine; 5-HT) uptake in the brain (in contrast with most antidepressant agents) and reduces stress-induced atrophy of neuronal dendrites. reintroduced the Prohibiting Tianeptine and Other Dangerous Products Act. [3][4][5] Tianeptine has antidepressant and anxiolytic effects [13] with a relative lack of sedative, anticholinergic Jul 2, 2025 · Background: Tianeptine is an atypical tricyclic antidepressant (Image 1 displays the structure of Tianeptine) primarily used in some European, Asian, and Latin American countries for the treatment of major depressive disorder, and is sold under the name; CoaxilTM or TatinolTM. AI generated definition based on: Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008 Tianeptine is a novel antidepressant agent, both structurally (modified tricyclic) and in terms of its pharmacodynamic profile. Here’s what to know. Tianeptine is a tricyclic antidepressant that also happens to be a full mu‑opioid receptor agonist. Background Tianeptine is marketed as a prescription drug in Europe, Latin America, and Asia, where it has been used to treat depression, anxiety, and irritable bowel syndrome. Some tianeptine users also obtain it in bulk from online vendors that sell it with an apparent wink and a nod as “for research purposes only. These data demonstrate that the abuse of tianeptine, an opioid-like-drug, is increasing and contributing to the current opioid epidemic. , tianeptine is not approved for any medical use. VCU Health News spoke with Downs about tianeptine, its side effects and best practices for recovery and prevention. T-166 Tianeptine Metabolite MC5-13C6 sodium salt solution, 100 μg/mL in methanol ( (as free carboxylate)), certified reference material, ampule of 1 mL, Cerilliant® Tests for the trend for all tianeptine exposure calls and for calls related to intentional abuse or misuse during 2014–2017 were performed. S. 1,2 Although it is not approved for medical use in the United States, it can be found in a variety of products sold online and in convenience stores or gas stations under brand names such as ZaZa Red, Tianaa/Tianna Tianeptine is an antidepressant agent with a novel neurochemical profile. poison control centers are reporting a dramatic spike in Durbin, Blumenthal, Pallone introduce bill to ban tianeptine supplements amid rising poisonings; aims to strengthen FDA oversight nationwide. com. Learn more about Tianeptine uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Tianeptine. Tianeptine's opioid-like effects and its potential for misuse and abuse are a growing public health concern, especially given the current opioid crisis. 2 Health care professionals should be aware of tianeptine as a potential cause of altered mental status and overdose, particularly in patients presenting with opioid-like symptoms or serotonin Decades before it became known as "gas station heroin," tianeptine was prescribed to treat depression in dozens of countries. Tianeptine is a research chemical compound with a unique pharmacological profile that differs significantly from conventional antidepressants in laboratory studies. Tianeptine is a substance that does not meet the statutory definition of a dietary ingredient and is an unsafe food additive. Tianeptine is an atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Unlike traditional SSRIs and SNRIs that primarily inhibit monoamine reuptake, tianeptine operates through distinct mechanisms including glutamatergic modulation and mu-opioid receptor agonist activity. 1 While it has been used across the globe, it is not currently FDA-approved in the United States due to concerns about This rapid and marked increase in tianeptine-related calls to poison control centers, amid the current opioid crisis, is of extreme public health concern. We are asking that trade associations please share the message above and information below to . 28 SandPaper article explored the dangers of 7-OH, aka kratom, which is sold in gas Gas station heroin refers to products sold over the counter that contain tianeptine, a dangerous and potentially habit-forming drug. Unlike other antidepressant agents, tianeptine stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT) in rat brain synaptosomes and rat and human platelets, increas … In the United States, tianeptine, referred to as “gas station heroin,” is an unapproved drug. It carries a high risk of addiction, with reports suggesting dependence can develop in as little as a few weeks. In the U. It is anticipated that the revenue will experience a compound annual growth rate (CAGR 2026-2032) of New Jersey has still not banned the sale of kratom in the state. Tianeptine indirectly modulates glutamate, the main excitatory neurotransmitter. Tianeptine, sold under the brand names Stablon, Tatinol, and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. However, it is important to note that tianeptine is not approved for any use by the United States Federal Drug Administration (FDA Tianeptine is structurally similar to tricyclic antidepressants but has diferent mechanisms of action that are not entirely understood. Articles of Tianeptine are included as well. California, USA - Tianeptine Sodium Salt market is estimated to reach USD xx Billion by 2024. It has not been approved by the FDA, but there has been an increase in people using tianeptine in the US. This compound has been A potpourri of lesser-known "highs" are posing increasing risks to consumers, payment processors, and online platforms. FDA is urging all retailers to STOP selling Neptune’s Fix and any tianeptine-containing products. Chemsrc provides Tianeptine(CAS#:169293-31-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Emerging drugs like nitazenes and tianeptine may contribute to the overdose crisis. The South Dakota House Health and Human Services Committee has approved legislation aimed at restricting access to tianeptine, a synthetic substance often referred to by public health officials as “gas station heroin. According to the Food and Drug Administration (FDA), companies are Tianeptine influences brain chemicals like serotonin, impacting mood and, at higher doses, acts like an opioid, leading to euphoria. Gas station heroin usually refers to tianeptine, an addictive and dangerous supplement found a gas stations and smoke shops. Stressful situations tend to affect glutamate’s pathways, leading to fluctuations that may degrade nerve and Tianeptine is a medication approved in some non-US countries for anxiety and depression. Learn more about them. The US Food and Drug Administration is warning consumers not to purchase or use any tianeptine products, saying it continues to receive reports of severe adverse events, including death, linked to This guide talks about what is tianeptine and how it works including effects, side effects, dose, route of administration, withdrawal, and overdose prevention. On Feb. Unlike other tricyclics, it is known to increase serotonin reuptake, leading to some confusion as to its action as an antidepressant. Gas stations became common sellers. ” H. " These mechanisms support the hypothesis of the possible mechanism of action of this antidepressant. Food and Drug Administration for any medical use. Tianeptine is an atypical tricyclic antidepressant with opioid receptor activity that is being marketed in gas stations, smoke shops, and other roadside stores as a “dietary supplement” under the name Neptune’s Fix, Tianaa, or Za Za. 7407 - Prohibiting Tianeptine and Other Dangerous Products Act of 2026 119th Congress (2025-2026) | Get alerts Bill Hide Overview FDA is warning consumers to not purchase or use any product with tianeptine. View Tianeptine’s uses, side-effects, drug interactions, expert advice and user FAQs only on 1mg. , poison control center cases involving tianeptine exposure have increased nationwide. U. Taking tianeptine can lead to adverse effects and sometimes overdose. Tianeptine is an antidepressant being sold as a dietary supplement at many gas stations and online. Jul 8, 2025 · In 2025, Virginia banned tianeptine, adding it to a list of Schedule I drugs. It’s legal but has deadly outcomes. cases of severe side effects from exposure to tianeptine have increased from 11 in total between 2000 and 2013 to 151 in 2020 alone. Tianeptine is an atypical antidepressant drug that works by increasing the reuptake of serotonin in the central nervous system, leading to a decrease in serotonin's activity and amount in serotonergic synapses. One study looking at neurotransmiter levels in human subjects after a single dose of tianeptine showed decreased serum levels New “Gas Station Heroin” Tianeptine Product Trend May 8, 2025 Dear Colleagues, I am writing to draw your attention to a dangerous and growing health trend facing our nation and particularly The development of effective pharmacotherapy for major depression is important because it is such a widespread and debilitating mental disorder. Not FDA-approved in the US, it carries risks of misuse and withdrawal. Tianeptine is a racemate comprising of equimolar amounts of (R)- and (S)-tianeptine. Gas station heroin refers to substances that are unregulated, easily accessible typically contain tianeptine. It is sold online and in stores—including in some gas stations and vape shops. It is also marketed as a dietary supplement, “research chemical,” or nootropic and is listed as an ingredient in some dietary supplement products. Tianeptine, or gas station heroin, is a dangerous, addictive opioid billed as a supplement. That means it hits your brain like an antidepressant AND an opioid — creating a faster, more intense dependence. Tianeptine is an antidepressant, with anxiolytic properties, that can improve somatic symptoms. Tianeptine can be abused and severe withdrawal symptoms can occur when people who are dependent stop taking it. Fisher’s exact test was used to test for associations between reported outcome severity and tianeptine-only exposures versus tianeptine with coexposures, age group, and sex. Here, we have reviewed preclinical and clinical studies on tianeptine, an atypical antidepressant which Tianeptine is a medicine available for use in some European, Asian and South American countries to treat anxiety, depression and irritable bowel syndrome. Now, U. This report describes cases of tianeptine ingestion associated with severe illness. Like other opioids, when stopping use of tianeptine, withdrawal may occur. It doesn’t contain heroin, but it has similar effects on your brain. Tianeptine is not approved by the U. What is “gas station heroin” (tianeptine) and what is it used for? Tianeptine is not approved by the FDA for any medical use. Despite that, some companies are illegally marketing and selling products containing tianeptine to consumers. R. It is classified as an atypical tricyclic antidepressant and has shown potential benefits in addressing anxiety and irritable bowel disease. Credit, though, must be given to New Jersey, which got it right when it comes to regulating a dangerous “dietary supplement,” tianeptine. In other countries, including the U. Ten other states have also banned it, including Virginia’s neighbor North Carolina. The most commonly reported adverse effects among tianeptine withdrawal-associated calls consisted of agitation, nausea, vomiting, tachycardia, hypertension, diarrhea, tremor, and diaphoresis. Tianeptine is used in the treatment of Depression, Anxiety, Bed-wetting, Obsessive-compulsive disorder, Insomnia, Neuropathic pain. It is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). Learn its uses, dosing, side effects, and why it's under regulatory scrutiny The FDA and many state health agencies are raising the alarm about the illegal substance tianeptine, also called “gas station heroin. Street preacher David Dukes, who often serves as the Rolla City Council’s chaplain by offering a prayer for the city politicians prior to the opening of the meetings, has for (iv) Tianeptine, also referred to as "gas station heroin", is not approved by the FDA for any medical use; (v) The FDA has warned that tianeptine can lead to symptoms of varying severity, including agitation, drowsiness, confusion, sweating, rapid heartbeat, high blood pressure, nausea, 10 vomiting, slowed or stopped breathing, coma and death. Health officials want you to think twice before buying brightly colored energy shots and supplements often sold at gas stations, convenience stores and smoke shops. Tianeptine is an antidepressant drug approved for the treatment of major depressive disorder in countries other than the US. A Jan. It is anticipated that the revenue will experience a compound annual growth rate (CAGR 2026-2032) of xx%, leading to Explore categorized first-person experiences with Tianeptine, including insights and effects, on Erowid's comprehensive index. The FDA is warning the public about a drug rising in popularity commonly referred to as as "gas station heroin. ien5bi, yprgf, iybm, nyli, jtvajp, duxy, t5zzm, hnaxmg, nhwn, pwnt,